ea0049oc3.3 | Receptors & Signalling | ECE2017
O'Reilly Michael
, Kempegowda Punith
, Walsh Mark
, Taylor Angela
, Manolopoulos Konstantinos
, Allwood William
, Semple Robert
, Hebenstreit Daniel
, Dunn Warwick
, Tomlinson Jeremy
, Arlt Wiebke
Polycystic ovary syndrome (PCOS) is prevalent metabolic disorder in women, associated with androgen excess and insulin resistance. These two major features are closely correlated, but the direction of causality remains unclear. Aldoketoreductase type 1C3 (AKR1C3) converts the androgen precursor androstenendione to testosterone (T), and is highly expressed in subcutaneous (SC) adipose tissue. We hypothesised that adipose tissue represents an important site linking androgen acti...